Compliment.
Paying a compliment will help put your date in a good mood.

Complimenting them on a piece of clothing or accessory can lead into further conversation.

Family and friends.
Ask your date if they have any siblings.

Ask your date about their friends.
Food and drinks.

If you are at a restaurant, this is an appropriate time to bring this topic up.

Ask what their favorite type of food or drink is.

Hobbies and interests.
Ask your date about what they enjoy doing in their free time.

Ask follow up questions on this area, since they enjoy their interests and should also enjoy talking about them.

Movies and music.
Ask about the most recent movie they have seen or a movie that they would like to see.

Ask about what music they like to listen to and/or who their favorite artist is.

Career and school.
Ask about what they think about school or their career.

Ask about what future school/career aspirations they have.

Current events.
Before going out on your first date, read up on the news, information on the local community, celebrity gossip, sports...

Vacation.
Ask them to tell you about their most recent vacation or about future travel plans.